We live in an era with many societal challenges. The big ones such as climate change, access to health, clean food/water and the energy transition require solutions. These solutions will be driven by DeepTech and entrepreneurs, together with an ecosystem of corporates, investors and governments. Most of the DeepTech researchers and inventors are not per se entrepreneurs. Therefore, there is clear need for Venture Builders who have the skills and experience to create impactful and successful startups in a repetitive way. One of the leading Venture Builders in DeepTech is HighTechXL. John is CEO of HighTechXL and professor of Entrepreneurship at Tilburg University. Previously, he was responsible for External Innovation at Johnson & Johnson Consumer. Before that, he worked as VP Alliances and Open Innovation at Royal Philips on multiple strategic partnerships and new business opportunities.